Diverse developmental strategies of X chromosome dosage compensation in eutherian mammals
نویسندگان
چکیده
منابع مشابه
X chromosome dosage compensation: how mammals keep the balance.
The development of genetic sex determination and cytologically distinct sex chromosomes leads to the potential problem of gene dosage imbalances between autosomes and sex chromosomes and also between males and females. To circumvent these imbalances, mammals have developed an elaborate system of dosage compensation that includes both upregulation and repression of the X chromosome. Recent advan...
متن کاملX-Chromosome dosage compensation.
In mammals, flies, and worms, sex is determined by distinctive regulatory mechanisms that cause males (XO or XY) and females (XX) to differ in their dose of X chromosomes. In each species, an essential X chromosome-wide process called dosage compensation ensures that somatic cells of either sex express equal levels of X-linked gene products. The strategies used to achieve dosage compensation ar...
متن کاملX-Chromosome Dosage Compensation
The X and Y chromosomes of placental and marsupial mammals originated from a pair of autosomes. Ohno hypothesised nearly 50 years ago that the expression levels of X-linked genes should be doubled to compensate for the degeneration of their Y-linked homologues during sex chromosome evolution. The advent of microarray and RNA (ribonucleic acid) sequencing technologies in the past decade prompted...
متن کاملDosage compensation in mammals.
Many organisms show major chromosomal differences between sexes. In mammals, females have two copies of a large, gene-rich chromosome, the X, whereas males have one X and a small, gene-poor Y. The imbalance in expression of several hundred genes is lethal if not dealt with by dosage compensation. The male-female difference is addressed by silencing of genes on one female X early in development....
متن کاملX chromosome dosage compensation in Drosophila.
a colon length of 15,000 crypts. The mean width of the observed adenomas was seven crypts (although this figure is an overestimate of x, because it was observed after any collisions had occurred, which presumably had the effect of increasing x). We analyzed the model assuming different values of n and determining whether these values can account for two observations: (i) the final figure of 300...
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ژورنال
عنوان ژورنال: The International Journal of Developmental Biology
سال: 2019
ISSN: 0214-6282
DOI: 10.1387/ijdb.180376as